13,14 The heart relies mainly on serum T3 because no significant myocyte intracellular deiodinase activity takes place, and it appears that T3, and not T4, is transported into the myocyte ( Figure 1 ). MD;, PhD From the Department of Medicine and the Feinstein Institute for Medical Research (I.K., S.D. North Shore University Hospital, Manhasset, and the Departments of Medicine (I.K., S.D.) and Cell Biology (I.K. 9,11 In contrast, all forms of hyperthyroidism are accompanied by TSH levels that are suppressed to 0.1 mIU/L. Thus the TSH test is the appropriate initial test to screen for thyroid dysfunction in a variety of clinical situations known to be affected by. Thyroid hormone causes decreased resistance in peripheral arterioles through a direct effect on VSM and decreased mean arterial pressure, which, when sensed in the kidneys, activates the renin-angiotensin-aldosterone system and increases renal sodium absorption.
In hypothyroidism, the cardiovascular effects are diametrically opposite and cardiac output may decrease by 30 to 50. 3 It is important to recognize, however, that the restoration of normal cardiovascular hemodynamics can occur without a significant increase in resting heart rate in the.
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